| Volume 96, No. 2: June 2017
Prof. Jay Mellies [biology 1999-] has won a two-year grant for $362,769 from the National Institutes of Health for a project entitled “Pch Super Family Regulators of Gram-Negative Pathogens”
Prof. Mellies will investigate a key regulatory protein that enables the pathogen E. coli to cause disease in children. The protein, called Pch, controls niche adaptation—how the bacterium can outcompete other members of the microbial community in the small intestine and manipulate the host immune system to its own advantage.
Pch proteins are found in several medically important bacteria, including Salmonella, Shigella and Klebsiella, and thus a greater understanding of the Pch family of proteins could lead to novel therapies. Prof. Mellies aims to understand how Pch proteins function on a molecular level.
Previously Mellies has studied , enteropathogenic E. coli (known as EPEC), one of the leading causes of diarrhea in the developing world.
Tags: Jay Mellies, NIH grant
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